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Sensorimotor cortex reorganization in subacute and chronic stroke: A neuronavigated TMS study

Sensorimotor cortex reorganization in subacute and chronic stroke: A neuronavigated TMS study

Authors: 
Yarossi, Mathew ; Adamovich, Sergei ; Tunik, Eugene
Year: 
2014
Journal: 
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Abstract: 

The integrity of the corticospinal system is an important biomarker for recovery from stroke. However, mapping the topography of the corticospinal system in subacute stroke is not trivial and how it changes over the course of recovery is poorly understood. We intend to use a transcranial magnetic stimulation (TMS) based mapping approach to quantify the topographic landscape of corticospinal activation in the ipsi- and contralesional sensorimotor cortices in the subacute and chronic phase of stroke. Mapping was conducted before (PRE) and after (POST), intervention in 10 chronic subjects and 8 subacute subjects. Reorganization was quantified in a unique way by dissociating reorganization attributed to changes in the expanse (area) of the sensorimotor territory, from that attributed to changes in the robustness of the activation (amplitude). In doing so, we observed differences in reorganization in the subacute and chronic stages indicating that recovery in different stages may not be guided by similar neurophysiological mechanisms of neuroplasticity.

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