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Safety of EEG–fMRI recordings in newborn infants at 3T: A study using a baby-size phantom

Safety of EEG–fMRI recordings in newborn infants at 3T: A study using a baby-size phantom

Authors: 
Vanhatalo, S., Alnajjar, A., Nguyen, V.T., Colditz, P. & Fransson, P.
Year: 
2013
Journal: 
Clinical Neurophysiology
Abstract: 

Objective

We aimed to study EEG electrode temperatures during MRI recordings using a neonatal-size phantom to establish the safety of neonatal EEG–MRI.

Methods

We constructed a phantom set-up for co-registration of EEG and MRI measurements with newborn size configurations. The set-up consisted of a spherical glass phantom fitted with a customised MRI-compatible 64-channel EEG cap and EEG amplifier. Temperatures were recorded during and after five different scanning sequences (two T2∗ sensitised BOLD fMRI, one T1-weighted and two T2-weighted spin echo) in five electrode locations using a thermistor that was integrated into the electrode housing. A temperature increase >4 °C was defined a priori as the safety limit.

Results

During fMRI and T1 sequences, none of the electrodes showed meaningful temperature changes. Only one MRI sequence (T2 with Max turbo factor 25; SAR 89%) caused temperature increase in one electrode (Fpz; +4.1 °C) that slightly exceeded our predefined safety limit, while the conventional T2 sequence was within safety limits (up to +1.7 °C).

Conclusions

Co-registration of EEG and fMRI can be considered safe in babies with respect to electrode heating, which is the primary safety concern.

Significance

The present findings open up a possibility to commence studies where EEG and MRI/fMRI are co-registered in human babies. Such studies hold significant promise of a better understanding of the early development of brain function and neurovascular coupling.

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