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Correlation between cortical theta activity and hippocampal volumes in health, mild cognitive impairment, and mild dementia

Correlation between cortical theta activity and hippocampal volumes in health, mild cognitive impairment, and mild dementia

Authors: 
Grunwald M., Busse F., Hensel A., Kruggel F., RiedelHeller S., Wolf H., Arendt T. & Gertz H.J.
Year: 
2001
Journal: 
Journal of Clinical Neurophysiology
Abstract: 

Cognitive decline is known to be associated with bothincreased θ power over frontal regions and hippocampal atrophy. The aimof this study was to reveal the relation between these parameters in groupswith mild dementia, mild cognitive impairment, and healthy control subjects.The authors examined a preliminary randomly selected sample of 39 right-handedsubjects joining the Leipzig Longitudinal Study of the Aged, consisting of 17normal elderly subjects, 12 patients with mild cognitive impairment, and 10patients with mild dementia assessed by Clinical Dementia Rating. All subjectswere between 75 and 85 years old (mean age, 78 years; standard deviation, 2.78years) and underwent EEG and brain MRI. Mean spectral power densities werecalculated, and hippocampal body volume was measured. Significant negativelinear correlations between θ power over frontal regions and hippocampalvolumes were found. The results support the assumption about a relationshipbetween hippocampal atrophy and θ power, and may be helpful for a betterunderstanding of the course of Alzheimer'sdisease.

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